1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate)

Base Information

• Chemical Name: 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate)
• CAS No.: 120475-78-7
• Molecular Formula: C₁₈H₂₂O₁₀
• Molecular Weight: 398.367
• Mol file: 120475-78-7.mol

Synonyms:1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate)

Chemical Property of 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate)

There total 3 articles about 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

succinic acid anhydride (108-30-5) + 1,4-dihydroxymethyl-2,5-dimethoxybenzaldehyde (51829-43-7) → 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate) (120475-78-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 24h; Ambient temperature;

DOI:10.1021/jm00127a039

Reference yield:

1,4-bis(acetoxymethyl)-2,5-dimethoxybenzene (52251-27-1) → 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate) (120475-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaOH, H₂₀ / tetrahydrofuran; methanol / Heating

2: 90 percent / Et₃N / dioxane / 24 h / Ambient temperature

With sodium hydroxide; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm00127a039

Reference yield:

1,4-bis(chloromethyl)-2,5-dimethoxybenzene (3752-97-4) → 1,4-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate) (120475-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / glacial acetic acid / Heating

2: 94 percent / NaOH, H₂₀ / tetrahydrofuran; methanol / Heating

3: 90 percent / Et₃N / dioxane / 24 h / Ambient temperature

With sodium hydroxide; water; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm00127a039

upstream raw materials:

succinic acid anhydride

1,4-dihydroxymethyl-2,5-dimethoxybenzaldehyde

1,4-bis(acetoxymethyl)-2,5-dimethoxybenzene

1,4-bis(chloromethyl)-2,5-dimethoxybenzene

Downstream raw materials:

2,5-bis(hydroxymethyl)-1,4-benzoquinone bis(hydrogen succinate)