2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

Base Information

Chemical Name:2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate
CAS No.:1283118-23-9
Molecular Formula:C₂₆H₂₆N₄O₉S₂
Molecular Weight:602.646
Hs Code.:

Synonyms:2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

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Chemical Property of 2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

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Technology Process of 2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

There total 5 articles about 2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.3%

: 1283117-66-7
6-(4-aminophenyl)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one

: 124-63-0
methanesulfonyl chloride

: 1283118-23-9
2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 5h;

Reference yield:

: 2001-29-8
1-(4-bromophenyl)-2-phenyl-ethan-1-one

: 1283118-23-9
2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / Reflux

2: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Inert atmosphere; Reflux

3: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

4: triethylamine / dichloromethane / 5 h / 0 °C

With hydrogenchloride; water; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 178686-24-3
3-ethoxy-4-hydroxy-5-nitrobenzaldehyde

: 1283118-23-9
2-ethoxy-4-(6-(4-(methylsulfonamido)phenyl)-2-oxo-5-phenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-6-nitrophenyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / Reflux

2: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Inert atmosphere; Reflux

3: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

4: triethylamine / dichloromethane / 5 h / 0 °C

With hydrogenchloride; water; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;