Technology Process of 2-(5-methoxy-2,3-methylendioxyphenoxy)benzyl bromide
There total 10 articles about 2-(5-methoxy-2,3-methylendioxyphenoxy)benzyl bromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
dichloromethane;
at 0 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 68 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature
2: 90 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 1 h / 0 °C
3: 95 percent / MnO2 / 1,2-dichloro-ethane / 12 h / sonication
4: 90 percent / m-CPBA, Na2HPO4 / CH2Cl2 / Heating
5: 93 percent / K2CO3 / acetone / 48 h / Heating
6: 97 percent / H2 / Pd-C / ethyl acetate
7: 77 percent / K2CO3, Cu, CuI / various solvent(s) / 1 h / 120 °C
8: 95 percent / NaBH4, BF3*Et2O / tetrahydrofuran / 1 h / 0 °C
9: 76 percent / PBr3 / CH2Cl2 / 1.5 h / 0 °C
With
manganese(IV) oxide; sodium tetrahydroborate; disodium hydrogenphosphate; copper(l) iodide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; phosphorus tribromide; copper; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / m-CPBA, Na2HPO4 / CH2Cl2 / Heating
2: 93 percent / K2CO3 / acetone / 48 h / Heating
3: 97 percent / H2 / Pd-C / ethyl acetate
4: 77 percent / K2CO3, Cu, CuI / various solvent(s) / 1 h / 120 °C
5: 95 percent / NaBH4, BF3*Et2O / tetrahydrofuran / 1 h / 0 °C
6: 76 percent / PBr3 / CH2Cl2 / 1.5 h / 0 °C
With
sodium tetrahydroborate; disodium hydrogenphosphate; copper(l) iodide; boron trifluoride diethyl etherate; hydrogen; phosphorus tribromide; copper; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; acetone;
