Fmoc-4,5-dehydro-l-leucine

Base Information

Chemical Name:Fmoc-4,5-dehydro-l-leucine
CAS No.:87720-55-6
Molecular Formula:C₂₁H₂₁NO₄
Molecular Weight:351.402
Hs Code.:29225090
DSSTox Substance ID:DTXSID20427199
Wikidata:Q82239905
Mol file:87720-55-6.mol

Synonyms:fmoc-4,5-dehydro-l-leucine;87720-55-6;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpent-4-enoic acid;Fmoc-4,5-dehydro-Leu-OH;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpent-4-enoic acid;Fmoc-deltaLeu-OH;MFCD00237651;Fmoc-(S)-2-methallylglycine;SCHEMBL14570616;DTXSID20427199;AKOS016344241;FD21882;DS-11793;Fmoc-4,5-dehydro-L-leucine, AldrichCPR;BB 0260167;CS-0101044;EN300-7313261;A862443;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpent-4-enoic acid;(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methyl-4-pentenoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpent-4-enoic?acid

Suppliers and Price of Fmoc-4,5-dehydro-l-leucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-4,5-dehydro-L-leucine
25mg
$ 312.00

Usbiological
Fmoc-4-
25mg
$ 312.00

Usbiological
Fmoc-4-
100mg
$ 297.00

Usbiological
Fmoc-4-
100mg
$ 283.00

Usbiological
Fmoc-4-
250mg
$ 273.00

Usbiological
Fmoc-4,5-dehydro-L-leucine 99+%
250mg
$ 259.00

Usbiological
Fmoc-4-
1g
$ 237.00

Usbiological
Fmoc-4-
100mg
$ 233.00

Usbiological
Fmoc-4-
250mg
$ 233.00

Usbiological
Fmoc-4-
1g
$ 233.00

Total 24 raw suppliers

Chemical Property of Fmoc-4,5-dehydro-l-leucine

Chemical Property:

Boiling Point:569.8±45.0 °C(Predicted)
PKA:3.74±0.10(Predicted)
PSA：75.63000
Density:1.223±0.06 g/cm3(Predicted)
LogP:4.33540
Storage Temp.:-15°C
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:351.14705815
Heavy Atom Count:26
Complexity:524

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-4,5-dehydro-L-leucine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES:CC(=C)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Uses Fmoc-4,5-dehydro-L-leucine is a reagent in the solid-phase preparation of ε-lysylcarbonylphenoxyacetic acids to study the selective inhibition of human aldose reductase over aldehyde reductase.

Technology Process of Fmoc-4,5-dehydro-l-leucine

There total 2 articles about Fmoc-4,5-dehydro-l-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 87392-13-0,905929-81-9
(2S)-2-amino-4-methylpent-4-enoic acid

: 87720-55-6,917099-00-4
N-fluoren-9-ylmethyloxycarbonyl-4,5-dehydro-L-leucine

Guidance literature:: With sodium carbonate; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1039/P19830000723

Reference yield: 32.0%

: 87325-65-3,88547-24-4
(R,S)-2-acetamido-4-methyl-4-pentenoic acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 87720-55-6,917099-00-4
N-fluoren-9-ylmethyloxycarbonyl-4,5-dehydro-L-leucine

Guidance literature:: (R,S)-2-acetamido-4-methyl-4-pentenoic acid; With ammonium hydroxide; In water; at 33 ℃; for 24h; pH=7.2; Enzymatic reaction;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium hydrogencarbonate; In water; at 20 ℃; for 5h;
DOI:10.1002/chem.201901888

Reference yield: 15.0%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-40-6
N-Fmoc L-Phe

: 71989-38-3,118488-18-9,204384-67-8
Fmoc-Tyr(tBu)-OH

: 87720-55-6,917099-00-4
N-fluoren-9-ylmethyloxycarbonyl-4,5-dehydro-L-leucine

: C₂₈H₃₅N₅O₇

Guidance literature:: N-fluoren-9-ylmethyloxycarbonyl-4,5-dehydro-L-leucine; With 4-methyl-morpholine; pyridine; 2,6-Dichlorobenzoyl chloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-(fluoren-9-ylmethoxycarbonyl)glycine; N-Fmoc L-Phe; Fmoc-Tyr(tBu)-OH; Further stages;
DOI:10.1002/pep2.24070