Fmoc-N-(tert-butyloxycarbonylethyl)glycine

Base Information

Chemical Name:Fmoc-N-(tert-butyloxycarbonylethyl)glycine
CAS No.:174799-89-4
Molecular Formula:C24H27 N O6
Molecular Weight:425.47
Hs Code.:29225090
DSSTox Substance ID:DTXSID80441275
Nikkaji Number:J817.520I
Wikidata:Q82257985
Mol file:174799-89-4.mol

Synonyms:174799-89-4;Fmoc-N-(tert-butyloxycarbonylethyl)glycine;Fmoc-N-(tert-butyloxycarbonylethyl)-glycine;N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-(3-(tert-butoxy)-3-oxopropyl)glycine;2-[9H-fluoren-9-ylmethoxycarbonyl-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]amino]acetic acid;Fmoc-N-(tert-butoxycarbonylethyl)-glycine;N-(Carboxymethyl)-N-Fmoc-b-alanine tert-butyl ester;Fmoc-Nglu(tBu)-OH;SCHEMBL7062622;Fmoc-{tBuOCO(CH2)2}Gly-OH;DTXSID80441275;MFCD05663768;AKOS015911501;CS-0324184;E70715;J-011037;N-(9-Fluorenylmethyloxycarbonyl)-N-(t-butyloxycarbonylethyl)-glycine;N-(9H-Fluoren-9-ylmethoxycarbonyl)-N-(3-tert-butoxy-3-oxopropyl)glycine;2-{[3-(tert-butoxy)-3-oxopropyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}acetic acid;b-Alanine,N-(carboxymethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,1-(1,1-dimethylethyl)ester(9ci)

Suppliers and Price of Fmoc-N-(tert-butyloxycarbonylethyl)glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fmoc-n-(tert-butyloxycarbonylethyl)-glycine
100mg
$ 75.00

Iris Biotech GmbH
Fmoc-Nglu(tBu)-OH
5 g
$ 607.50

Iris Biotech GmbH
Fmoc-Nglu(tBu)-OH
1 g
$ 170.10

Iris Biotech GmbH
Fmoc-Nglu(tBu)-OH
500 mg
$ 109.35

Iris Biotech GmbH
Fmoc-Nglu(tBu)-OH
25 g
$ 2430.00

Crysdot
Fmoc-N-(tert-butyloxycarbonylethyl)glycine 95+%
5g
$ 734.00

Chemenu
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(3-(tert-butoxy)-3-oxopropyl)glycine 95%
5g
$ 693.00

American Custom Chemicals Corporation
FMOC-N-(TERT-BUTYLOXYCARBONYLETHYL)-GLYCINE 95.00%
100MG
$ 673.00

AK Scientific
Fmoc-N-(tert-butyloxycarbonylethyl)-glycine
100mg
$ 104.00

Activate Scientific
N-(Carboxymethyl)-N-Fmoc-b-alanine tert-butyl ester 95+%
1 g
$ 443.00

Total 7 raw suppliers

Chemical Property of Fmoc-N-(tert-butyloxycarbonylethyl)glycine

Chemical Property:

Boiling Point:597.5±43.0 °C(Predicted)
PKA:3.82±0.10(Predicted)
PSA：93.14000
Density:1.239±0.06 g/cm3(Predicted)
LogP:4.05390
Storage Temp.:Store at?0-5°C
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:425.18383758
Heavy Atom Count:31
Complexity:635

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-n-(tert-butyloxycarbonylethyl)-glycine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CCN(CC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of Fmoc-N-(tert-butyloxycarbonylethyl)glycine

There total 11 articles about Fmoc-N-(tert-butyloxycarbonylethyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 174799-87-2
2-((3-(tert-butoxy)-3-oxopropyl)amino)acetic acid

: 174799-89-4
N-fluorenylmethoxycarbonyl-N′-carboxymethyl-β-alanine-t-butyl ester

Guidance literature:: With triethylamine; In acetonitrile; for 4h; Ambient temperature;
DOI:10.1021/jo961580e

Reference yield: 47.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: HN(EtCO₂^tBu)-Gly-OMe

: 174799-89-4
N-fluorenylmethoxycarbonyl-N′-carboxymethyl-β-alanine-t-butyl ester

Guidance literature:: HN(EtCO₂^tBu)-Gly-OMe; With sodium hydroxide; In methanol; water; at 40 ℃; for 14h;

(fluorenylmethoxy)carbonyl chloride; With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 3h;
DOI:10.1039/c8cc04407d

Reference yield:

: 18605-26-0
3-(((benzyloxy)carbonyl)amino)propionic tert-butyl ester

: 174799-89-4
N-fluorenylmethoxycarbonyl-N′-carboxymethyl-β-alanine-t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol; acetic acid / 4 h / 3102.9 Torr / Ambient temperature

2: 1.) Et₃N, MgSO₄, 2.) NaBH₄ / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h)

3: 91.1 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h

4: 89.2 percent / H₂ / Pd/C / methanol / 4 h / 3102.9 Torr

5: 76.9 percent / aq. Et₃N / acetonitrile / 4 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; magnesium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo961580e