4-allyloxyphenylacetic acid

Base Information

• Chemical Name: 4-allyloxyphenylacetic acid
• CAS No.: 72224-22-7
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 72224-22-7.mol

Synonyms:4-allyloxyphenylacetic acid

Chemical Property of 4-allyloxyphenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-allyloxyphenylacetic acid

There total 5 articles about 4-allyloxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

allyl (p-allyloxyphenyl)acetate (851318-54-2) → 4-allyloxyphenylacetic acid (72224-22-7)

Guidance literature:

With sodium hydroxide; In methanol; at 35 ℃; for 2h;

DOI:10.1002/ejoc.201300072

Reference yield: 92.0%

4-hydroxyphenylacetate (156-38-7) + allyl bromide (106-95-6) → 4-allyloxyphenylacetic acid (72224-22-7)

Guidance literature:

4-hydroxyphenylacetate; allyl bromide; With potassium carbonate; In ethanol; at 20 ℃; for 5h;

With potassium hydroxide; In ethanol; for 12h;

DOI:10.1248/cpb.c14-00351

Reference yield:

4-hydroxyphenylacetate (156-38-7) → 4-allyloxyphenylacetic acid (72224-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere

2: sodium hydroxide / methanol / 2 h / 35 °C

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201300072

upstream raw materials:

allyloxy-4 phenylacetate d' ethyle

4-hydroxyphenylacetate

allyl bromide

(4-hydroxy-phenyl)-acetic acid ethyl ester

Downstream raw materials:

allyloxy-4 phenylacetate d' ethyle

SCH 71450

C₁₁H₁₁ClO₂

N-[2,4-bis(benzyloxy)phenethyl]-2-(4-allyloxyphenyl)acetamide

Refernces

• 1、 Xu, Xi,Wang, Jubo,Wang, Min,Yuan, Xinyu,Li, Lei,Zhang, Chao,Huang, Huidan,Jing, Tian,Wang, Chenchen,Tong, Chao,Zhou, Liwen,Meng, Ying,Xu, Pengfei,Kou, Junping,Qiu, Zhixia,Li, Zhiyu,Bian, Jinlei. "Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site". supporting information. p. 4588 - 4611. Retrieved 2021/05/04.
• 2、 -. "Macrocyclic glutaminase GLS1 inhibitor or pharmaceutically acceptable salt thereof and preparation method and application thereof". Paragraph 0086; 0088-0090. . Retrieved 2020/08/02.