N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine
CAS No.:1438073-92-7
Molecular Formula:C₂₅H₂₈ClFN₄O₄
Molecular Weight:502.973
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Suppliers and Price of N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

There total 14 articles about N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1438084-71-9
6-(3-chloropropyl)octahydro-[1,4]dioxino[2,3-c]pyridine

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1438073-92-7
N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1438073-92-7
N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / isopropyl alcohol; acetone / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrabutylammomium bromide; sodium hydroxide / water / 72 h / 55 °C

3.1: hydrogenchloride / methanol / 1 h / 20 °C

4.1: potassium carbonate / acetone / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With hydrogenchloride; osmium(VIII) oxide; tetrabutylammomium bromide; potassium carbonate; 4-methylmorpholine N-oxide; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438073-92-7
N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-[1,4]dioxino[2,3-c]pyridin-6(7H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 5 h / 88 °C

2: water; sodium hydroxide / methanol / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;