Propargyl-PEG5-alcohol

Base Information

• Chemical Name: Propargyl-PEG5-alcohol
• CAS No.: 1036204-60-0
• Molecular Formula: C₁₃H₂₄O₆
• Molecular Weight: 276.33
• Mol file: 1036204-60-0.mol

Synonyms:3,6,9,12,15-pentaoxaoctadec-17-yn-1-ol

Chemical Property of Propargyl-PEG5-alcohol

Chemical Property:

• Boiling Point: 368.1±37.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• Density: 1.078±0.06 g/cm3(Predicted)
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-peg5-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Propargyl-PEG6-alcohol is alkyne linker that can react with azide compounds via copper catalyzed azide-alkyne Click Chemistry. The hydrophilic PEG8 spacer increases solubility in aqueous environment.

Technology Process of Propargyl-PEG5-alcohol

There total 2 articles about Propargyl-PEG5-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.86%

Pentaethylene glycol (4792-15-8) + propargyl bromide (106-96-7) → 3,6,9,12,15-pentaoxaoctadec-17-yn-1-ol (1036204-60-0)

Guidance literature:

Pentaethylene glycol; With sodium hydride; In 1,4-dioxane; mineral oil; for 0.333333h; Inert atmosphere; Cooling with ice;

propargyl bromide; In 1,4-dioxane; mineral oil; at 20 ℃; for 4h; Inert atmosphere; Cooling with ice;

Reference yield: 30.0%

→ 3,6,9,12,15-pentaoxaoctadec-17-yn-1-ol (1036204-60-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

In tetrahydrofuran; toluene; at 20 ℃; for 21h; Inert atmosphere;

Reference yield: 91.0%

3,6,9,12,15-pentaoxaoctadec-17-yn-1-ol (1036204-60-0) + methanesulfonyl chloride (124-63-0) → C14H26O8S (1036204-62-2)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.tetlet.2008.03.130

upstream raw materials:

Pentaethylene glycol

propargyl bromide

Downstream raw materials:

C₁₄H₂₆O₈S

4-[16-hydroxy-2,5,8,11,14-pentaoxahexadecyl]-1-[3-(2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol-N-yl)-propyl]-1H-[1,2,3]-triazole

C₁₃H₂₃BrO₅

3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine