Propargyl-PEG5-amine

Base Information

Chemical Name:Propargyl-PEG5-amine
CAS No.:1589522-46-2
Molecular Formula:C₁₃H₂₅NO₅
Molecular Weight:275.345
Hs Code.:
Mol file:1589522-46-2.mol

Synonyms:

Suppliers and Price of Propargyl-PEG5-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
Propargyl-PEG5-amine 98%
500 MG
$ 680.00

BroadPharm
Propargyl-PEG5-amine 98%
1 G
$ 1020.00

Apolloscientific
Propargyl-PEG5-amine
250mg
$ 759.00

Acrotein
Propargyl-PEG5-NH2 97%
0.5g
$ 302.50

Acrotein
Propargyl-PEG5-NH2 97%
0.25g
$ 201.66

Total 15 raw suppliers

Chemical Property of Propargyl-PEG5-amine

Chemical Property:

Boiling Point:360.4±37.0 °C(Predicted)
PKA:8.74±0.10(Predicted)
Density:1.049±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG5-amine 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.

Technology Process of Propargyl-PEG5-amine

There total 6 articles about Propargyl-PEG5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1-azido-3,6,9,12,15-pentaoxaoctadec-17-yne

: 1589522-46-2,956348-61-1
3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine

Guidance literature:: 1-azido-3,6,9,12,15-pentaoxaoctadec-17-yne; In tetrahydrofuran; at 20 ℃; for 1152h; polymer-supported triphenylphosphine

With water; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.3390/molecules180911639

Reference yield: 8.4%

: 1589522-46-2,956348-61-1
3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 4792-15-8
Pentaethylene glycol

: 1589522-46-2,956348-61-1
3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: potassium hydroxide / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 h / 45 °C / Inert atmosphere

4.1: polymer-supported triphenylphosphine / tetrahydrofuran / 1152 h / 20 °C

4.2: 48 h / 20 °C

With sodium azide; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules180911639