2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-Methylethyl]aMino]Methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester

Base Information

Chemical Name:2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-Methylethyl]aMino]Methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester
CAS No.:601490-35-1
Molecular Formula:C₁₅H₁₆F₃NO₄
Molecular Weight:331.292
Hs Code.:

Synonyms:(Z)-3-((S)-2-Hydroxy-1-methyl-ethylamino)-2-(2,3,4-trifluoro-benzoyl)-acrylic acid ethyl ester

Suppliers and Price of 2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-Methylethyl]aMino]Methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster
500mg
$ 1320.00

Medical Isotopes, Inc.
2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster
50 mg
$ 650.00

Total 2 raw suppliers

Chemical Property of 2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-Methylethyl]aMino]Methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester

Chemical Property:

Boiling Point:459.2±45.0 °C(Predicted)
PKA:14.48±0.10(Predicted)
Density:1.310±0.06 g/cm3(Predicted)
Solubility.:Acetone, DCM, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester is an trifluorinated analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.

Technology Process of 2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-Methylethyl]aMino]Methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester

There total 2 articles about 2,3,4-Trifluoro-α-[[[(1S)-2-hydroxy-1-Methylethyl]aMino]Methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2749-11-3
(S)-Alaninol

: 122-51-0
orthoformic acid triethyl ester

: 157766-27-3
ethyl 3-(2,3,4-trifluorophenyl)-3-oxopropanoate

: 601490-35-1
(Z)-3-((S)-2-Hydroxy-1-methyl-ethylamino)-2-(2,3,4-trifluoro-benzoyl)-acrylic acid ethyl ester

Guidance literature:: orthoformic acid triethyl ester; ethyl 3-(2,3,4-trifluorophenyl)-3-oxopropanoate; With acetic anhydride; at 110 ℃;

(S)-Alaninol; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0960-894X(03)00399-8

Reference yield:

: 157373-08-5
2,3,4-trifluoro-benzoyl chloride

: 601490-35-1
(Z)-3-((S)-2-Hydroxy-1-methyl-ethylamino)-2-(2,3,4-trifluoro-benzoyl)-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / nBuLi / tetrahydrofuran / -78 - 20 °C

2.1: Ac₂O / 110 °C

2.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

With n-butyllithium; acetic anhydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00399-8