(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

Base Information

Chemical Name:(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide
CAS No.:1021436-82-7
Molecular Formula:C₄₅H₅₈N₆O₁₀S₂
Molecular Weight:907.122
Hs Code.:

(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1<sup>(23)</sup>,17,19,21,24-pentaene-5-carboxamide

Synonyms:(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

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Chemical Property of (3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

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Technology Process of (3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

There total 6 articles about (3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 630421-49-7
(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride

: C₃₆H₄₆N₄O₈S

: 1021436-82-7
(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

Guidance literature:: With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;
DOI:10.1016/j.bmcl.2012.08.106

Reference yield:

: 1021437-85-3
methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9,20-trioxo-3,4,6,7,8,9,12,13,14,15,19,20-dodecahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

: 1021436-82-7
(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: silver(l) oxide / N,N-dimethyl-formamide / 1.5 h / 100 °C

2: water; lithium hydroxide / methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; silver(l) oxide; lithium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.106

Reference yield:

: 1021438-11-8
methyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-20-[(2-methyl-1,3-thiazol-4-yl)methoxy]-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-etheno-2,5-methanopyrido[4,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

: 1021436-82-7
(3R,5S,8S)-8-cyclohexyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-18-methoxy-13,13-dimethyl-22-[(2-methyl-1,3-triazol-4-yl)methoxy]-7,10-dioxo-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1(3,6).0(20,24)]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.106