methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

Base Information

Chemical Name:methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate
CAS No.:104840-68-8
Molecular Formula:C₂₄H₃₀O₄Si
Molecular Weight:410.585
Hs Code.:

Synonyms:methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

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Chemical Property of methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

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Technology Process of methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

There total 8 articles about methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 104840-63-3
Methyl 4-(tert-Butyldiphenylsiloxy)-5-methyl-hexa-2(E),5-dienoate

: 104840-68-8
methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

: 104855-07-4
Methyl 4(R)-(tert-Butyldiphenylsiloxy)-5,6-epoxy-5(R)-methyl-but-2(E)-enoate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 12h;
DOI:10.1248/cpb.38.1451

Reference yield:

: 5927-18-4
trimethyl phosphonoacetate

: 356787-10-5
(2R,3S)-2-(tert-butyldiphenylsilyl)oxy-3,4-epoxy-3-methylbutanal

: 104840-68-8
methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

: methyl (2Z,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

Guidance literature:: trimethyl phosphonoacetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 0.5h;

(2R,3S)-2-(tert-butyldiphenylsilyl)oxy-3,4-epoxy-3-methylbutanal; In acetonitrile; at 20 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(01)00149-5

Reference yield:

: 97971-47-6
2-(tert-Butyldiphenylsiloxy)-3-methyl-but-3-enal

: 104840-68-8
methyl (2E,4R,5S)-4-(tert-butyldiphenylsilyl)oxy-5,6-epoxy-5-methylhex-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) benzene, room temp., 30 min., 2) benzene, 30 min.

2: 33 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 12 h

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1248/cpb.38.1451