methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

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Chemical Name:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate
CAS No.:1383786-49-9
Molecular Formula:C₂₅H₂₃N₃O₇
Molecular Weight:477.474
Hs Code.:

Synonyms:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

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Chemical Property of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

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Technology Process of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

There total 8 articles about methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 622-33-3
N-benzyloxyamine

: 1383786-48-8
methyl 2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)-5-picolinamidobenzoate

: 1383786-49-9
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

Guidance literature:: In toluene; Reflux; Dean-Stark;
DOI:10.1021/jm500109z

Reference yield: 20.0%

: 1383786-49-9
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

Guidance literature:

Reference yield:

: 2965-22-2
methyl 2-fluoro-5-nitro-benzoate

: 1383786-49-9
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-picolinamidobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / Inert atmosphere; Reflux

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide / 12 h / 20 °C

4.1: toluene / Reflux; Dean-Stark

With 5%-palladium/activated carbon; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm500109z