5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

Base Information

Chemical Name:5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid
CAS No.:1040377-28-3
Molecular Formula:C₂₃H₂₆Cl₂FN₃O₇
Molecular Weight:546.38
Hs Code.:

Synonyms:5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

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Chemical Property of 5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

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Technology Process of 5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

There total 5 articles about 5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1040377-26-1
C₂₅H₃₀Cl₂FN₃O₇

: 1040377-28-3
5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

Guidance literature:: C₂₅H₃₀Cl₂FN₃O₇; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield:

: 756520-66-8
1-(2,6-dichloro-3-fluorophenyl)ethanol

: 1040377-28-3
5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: Reflux

2.1: dmap / N,N-dimethyl-formamide / 20 °C

3.1: sodium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 90 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

4.2: pH 5

With dmap; water; sodium acetate; sodium hydride; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 290835-85-7
2',6'-dichloro-3'-fluoroacetophenone

: 1040377-28-3
5-[(2,6-dichloro-3-fluorophenyl)ethoxy]-6-{(ert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

1.2: 0 °C / pH 6

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: Reflux

3.1: dmap / N,N-dimethyl-formamide / 20 °C

4.1: sodium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 90 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

5.2: pH 5

With dmap; sodium tetrahydroborate; water; sodium acetate; sodium hydride; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;