O-acetoacetylbenzamide oxime

Base Information

• Chemical Name: O-acetoacetylbenzamide oxime
• CAS No.: 81467-48-3
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.228
• Mol file: 81467-48-3.mol

Synonyms:O-acetoacetylbenzamide oxime

Chemical Property of O-acetoacetylbenzamide oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-acetoacetylbenzamide oxime

There total 3 articles about O-acetoacetylbenzamide oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + N-hydroxyl-benzamidine (613-92-3) → O-acetoacetylbenzamide oxime (81467-48-3)

Guidance literature:

In chloroform; at 0 - 5 ℃; for 1.5h;

Reference yield:

(E)-N'-hydroxybenzimidamide (613-92-3) → C11H12N2O3 (81467-48-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/S0040-4039(00)02288-7

Reference yield:

benzonitrile (100-47-0) → C11H12N2O3 (81467-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent aq. NH₂OH / ethanol / 1 h / Heating

2: iPr₂NEt / CH₂Cl₂ / 0 °C

With hydroxylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1016/S0040-4039(00)02288-7

upstream raw materials:

4-methyleneoxetan-2-one

N-hydroxyl-benzamidine

(E)-N'-hydroxybenzimidamide

benzonitrile

Downstream raw materials:

3-phenyl-4H-[1,2,4]oxadiazol-5-one

5-acetonyl-3-phenyl-1,2,4-oxadiazole

N-hydroxyl-benzamidine