2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

Base Information

Chemical Name:2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide
CAS No.:1338220-95-3
Molecular Formula:C₄₀H₄₉N₃O₃Si₂
Molecular Weight:676.018
Hs Code.:

Synonyms:2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

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Chemical Property of 2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

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Technology Process of 2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

There total 10 articles about 2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 1338220-75-9
5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(naphthalen-1-yl)pyrazin-2-amine

: 1338220-95-3
2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

Guidance literature:: With pyridine; dmap; at 50 ℃; for 16h; Inert atmosphere;

Reference yield:

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 79-37-8
oxalyl dichloride

: 1338220-75-9
5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(naphthalen-1-yl)pyrazin-2-amine

: 114774-40-2
2-(4-((tert-butyldimethylsilyl)oxy)phenyl)acetic acid

: 1338220-95-3
2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

Guidance literature:: With dmap; In pyridine; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1338220-95-3
2-[4-(tert-butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethyl silyloxy)phenyl}-3-(naphthalen-1-yl)pyrazin-2-yl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide; water

2: hydrogenchloride; n-butyllithium / hexane; tetrahydrofuran

3: sodium carbonate / dichlorobis(triphenylphosphine)palladium[II] / toluene; ethanol; water

4: N-Bromosuccinimide / water; dimethyl sulfoxide

5: sodium carbonate / dichlorobis(triphenylphosphine)palladium[II] / toluene; ethanol; water

6: dmap / dichloromethane; N,N-dimethyl-formamide; pyridine; water

With hydrogenchloride; dmap; N-Bromosuccinimide; n-butyllithium; sodium carbonate; dichlorobis(triphenylphosphine)palladium[II]; In tetrahydrofuran; pyridine; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;