4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)

Base Information

• Chemical Name: 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)
• CAS No.: 357623-46-2
• Molecular Formula: C₂₈H₂₃N₅O₂
• Molecular Weight: 461.523
• Mol file: 357623-46-2.mol

Synonyms:4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)

Chemical Property of 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)

Chemical Property:

Purity/Quality:

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Technology Process of 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol)

There total 4 articles about 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-cyanobenzaldehyde (105-07-7) + edaravone (89-25-8) → 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) (357623-46-2)

Guidance literature:

With Phloroglucin-trisulfatester; silica gel; In ethanol; at 75 ℃; for 0.05h; Green chemistry;

DOI:10.1016/S1872-2067(11)60477-4

Reference yield: 95.0%

ethyl acetoacetate (141-97-9) + phenylhydrazine (100-63-0) + 4-cyanobenzaldehyde (105-07-7) → 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) (357623-46-2)

Guidance literature:

ethyl acetoacetate; phenylhydrazine; With polyethylene glycol-bonded triethylammonium L-prolinate; In neat (no solvent); at 60 ℃; for 0.0333333h; Ionic liquid;

4-cyanobenzaldehyde; In neat (no solvent); at 60 ℃; for 0.166667h; Ionic liquid;

DOI:10.1039/d0nj02682d

Reference yield: 89.0%

2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one (27420-41-3) + 4-cyanobenzaldehyde (105-07-7) + edaravone (89-25-8) → 4,4'-[(4-cyanophenyl)methylene]-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) (357623-46-2) + 4-((2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)benzonitrile

Guidance literature:

4-cyanobenzaldehyde; edaravone; With copper ferrite; at 85 ℃; for 0.5h;

2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one; at 85 ℃; for 1.5h;

DOI:10.1007/s11164-017-3022-4

upstream raw materials:

4-cyanobenzaldehyde

edaravone

phenylhydrazine

ethyl acetoacetate