FMOC-(S)-3-AMINO-4-(4-CHLORO-PHENYL)-BUTYRIC ACID

Base Information

• Chemical Name: FMOC-(S)-3-AMINO-4-(4-CHLORO-PHENYL)-BUTYRIC ACID
• CAS No.: 270596-43-5
• Molecular Formula: C25H22 Cl N O4
• Molecular Weight: 435.9
• Mol file: 270596-43-5.mol

Synonyms:(S)-N-(9-Fluorenylmethyloxycarbonyl)-3-amino-4-(4-chlorophenyl)butyric acid

Chemical Property of FMOC-(S)-3-AMINO-4-(4-CHLORO-PHENYL)-BUTYRIC ACID

Chemical Property:

• Vapor Pressure: 5.62E-18mmHg at 25°C
• Boiling Point: 653.6°Cat760mmHg
• PKA: 4.36±0.10(Predicted)
• Flash Point: 349.1°C
• PSA: 75.63000
• Density: 1.313g/cm³
• LogP: 5.65540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-4-chloro-L-beta-homophenylalanine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-(S)-3-AMINO-4-(4-CHLORO-PHENYL)-BUTYRIC ACID

There total 2 articles about FMOC-(S)-3-AMINO-4-(4-CHLORO-PHENYL)-BUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + (S)-3-amino-4-(4-chlorophenyl)butanoic acid (270596-41-3,678969-20-5,678969-21-6) → N-(9-fluorenylmethyloxycarbonyl)-L-β-homo-p-chlorophenylalanine (270596-43-5,331763-60-1)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 24h;

DOI:10.1016/S0040-4020(02)00513-6

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + (S)-3-amino-4-(4-chlorophenyl)butanoic acid (270596-41-3,678969-20-5,678969-21-6) → N-(9-fluorenylmethyloxycarbonyl)-L-β-homo-p-chlorophenylalanine (270596-43-5,331763-60-1)

Guidance literature:

allylmagnesium bromide; With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

3,4-diacetoxybenzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 0.166667h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ol020127o

Reference yield: 93.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + N-(9-fluorenylmethyloxycarbonyl)-L-β-homo-p-chlorophenylalanine (270596-43-5,331763-60-1) → 4-(4-chloro-phenyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid pentafluorophenyl ester

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(02)00513-6

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

(S)-3-amino-4-(4-chlorophenyl)butanoic acid

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