(Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

Base Information

Chemical Name:(Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester
CAS No.:192370-28-8
Molecular Formula:C₂₁H₂₃N₅O₅
Molecular Weight:425.444
Hs Code.:

Synonyms:(Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

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Chemical Property of (Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

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Technology Process of (Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

There total 10 articles about (Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 192370-27-7
(Z)-5-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-hydroxy-ethyl)-pent-3-enoic acid ethyl ester

: 192370-28-8
(Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

Guidance literature:: With Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; for 4h; 0 deg C to room temp.;
DOI:10.1016/S0040-4039(97)00871-X

Reference yield:

: 4330-20-5
N-3-benzoylthymine

: 192370-33-5
(Z)-3-(2-Azido-ethyl)-5-hydroxy-pent-3-enoic acid ethyl ester

: 192370-28-8
(Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1081/NCN-120022838

Reference yield:

: 51442-80-9
5-(tetrahydro-2H-pyran-2-yloxy)-2-pentyn-1-ol

: 192370-28-8
(Z)-3-(2-Azido-ethyl)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pent-3-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: Red-Al / tetrahydrofuran / 0 - 20 °C

1.2: 90 percent / N-iodosuccinimide / tetrahydrofuran / 0.17 h / -78 °C

2.1: 97 percent / imidazole / tetrahydrofuran / 16 h / 20 °C

3.1: Zn / various solvent(s) / 0.5 h / Heating

3.2: 88 percent / N,N'-dimethyl-N,N'-propyleneurea; Pd(PPh₃)4 / 2 h / 65 °C

4.1: 80 percent / pyridinium p-toluenesulfonate / ethanol / 2.5 h / 45 °C

5.1: 68 percent / LiN₃; PPh₃; CBr₄ / dimethylformamide / 16 h / 0 °C

6.1: HF*pyridine / acetonitrile / 2.5 h / 20 °C

7.1: PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; lithium azide; carbon tetrabromide; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; pyridine hydrogenfluoride; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; zinc; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1081/NCN-120022838