2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

Base Information

Chemical Name:2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide
CAS No.:1355998-33-2
Molecular Formula:C₂₄H₂₂N₄O
Molecular Weight:382.465
Hs Code.:

Synonyms:2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

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Chemical Property of 2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

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Technology Process of 2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

There total 8 articles about 2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1356000-65-1
tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

: 1355998-33-2
2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm201394e

Reference yield:

: 1032349-96-4
tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

: 1355998-33-2
2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

5.1: potassium hydroxide / ethanol; water / 2 h / 60 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 1 h / Inert atmosphere

6.2: 23 h / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201394e

Reference yield:

: 1032349-97-5
tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate

: 1355998-33-2
2-(4-(1-aminocyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol; water / 2 h / 60 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 1 h / Inert atmosphere

5.2: 23 h / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201394e