tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate
CAS No.:1356000-65-1
Molecular Formula:C₂₉H₃₀N₄O₃
Molecular Weight:482.582
Hs Code.:

Synonyms:tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

There total 5 articles about tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1356001-73-4
2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylic acid

: 1356000-65-1
tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

Guidance literature:: 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; N,N-dimethyl-formamide; for 1h; Inert atmosphere;

With ammonium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; for 23h; Inert atmosphere;
DOI:10.1021/jm201394e

Reference yield:

: 1356000-16-2
methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

: 1356000-65-1
tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With ammonia; In methanol; at 130 ℃; for 1.5h; microwave irradiation;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1356000-65-1
tert-butyl 1-(4-(7-carbamoyl-3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium perbromide hydrobromide / tetrahydrofuran / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Molecular sieve; Reflux

3: ammonia / methanol / 1.5 h / 130 °C / microwave irradiation

With pyridinium perbromide hydrobromide; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol;