(Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile

Base Information

• Chemical Name: (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile
• CAS No.: 1338081-26-7
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.276
• Mol file: 1338081-26-7.mol

Synonyms:(Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile

Chemical Property of (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile

There total 2 articles about (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile (1338081-25-6) + methylamine (74-89-5) → (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile (1338081-26-7)

Guidance literature:

With potassium carbonate; In ethanol; water; for 4h; Reflux;

DOI:10.1021/jo2012384

Reference yield:

5-cyano-2-methoxybenzaldehyde (21962-53-8) → (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile (1338081-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic anhydride / 4 h / 80 °C

2: potassium carbonate / ethanol; water / 4 h / Reflux

With sodium acetate; potassium carbonate; In ethanol; water; acetic anhydride;

DOI:10.1021/jo2012384

Reference yield: 95.0%

(Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile (1338081-26-7) → (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-hydroxybenzonitrile (1338081-27-8)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo2012384

upstream raw materials:

(Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile

methylamine

5-cyano-2-methoxybenzaldehyde

Downstream raw materials:

(Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-hydroxybenzonitrile