(Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile

Base Information

• Chemical Name: (Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile
• CAS No.: 1338081-25-6
• Molecular Formula: C₁₃H₁₀N₂O₃
• Molecular Weight: 242.234
• Mol file: 1338081-25-6.mol

Synonyms:(Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile

Chemical Property of (Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile

There total 1 articles about (Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-cyano-2-methoxybenzaldehyde (21962-53-8) + N-acetylglycine (543-24-8) → (Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile (1338081-25-6)

Guidance literature:

With sodium acetate; In acetic anhydride; at 80 ℃; for 4h;

DOI:10.1021/jo2012384

Reference yield: 60.0%

(Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile (1338081-25-6) + methylamine (74-89-5) → (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile (1338081-26-7)

Guidance literature:

With potassium carbonate; In ethanol; water; for 4h; Reflux;

DOI:10.1021/jo2012384

Reference yield:

(Z)-4-methoxy-3-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)benzonitrile (1338081-25-6) → (Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-hydroxybenzonitrile (1338081-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol; water / 4 h / Reflux

2: boron tribromide / dichloromethane / 4 h / 0 °C / Inert atmosphere

With boron tribromide; potassium carbonate; In ethanol; dichloromethane; water;

DOI:10.1021/jo2012384

upstream raw materials:

5-cyano-2-methoxybenzaldehyde

N-acetylglycine

Downstream raw materials:

(Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-hydroxybenzonitrile

(Z)-3-((1,2-dimethyl-5-oxo-1H-imidazol-4(5H)-ylidene)methyl)-4-methoxybenzonitrile