N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

Base Information

Chemical Name:N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide
CAS No.:1253190-73-6
Molecular Formula:C₃₁H₃₁Cl₄N₃O₄
Molecular Weight:651.417
Hs Code.:

Synonyms:N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

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Chemical Property of N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

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Technology Process of N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

There total 4 articles about N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1253191-32-0
1-benzyl-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido)piperidine-3-carboxamide

: 1253190-73-6
N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

Guidance literature:: With carbonochloridic acid 1-chloro-ethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; at 25 ℃; for 19h; Reflux;

Reference yield: 45.0%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 1253191-32-0
1-benzyl-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido)piperidine-3-carboxamide

: 1253190-73-6
N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

Guidance literature:: carbonochloridic acid 1-chloro-ethyl ester; 1-benzyl-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido)piperidine-3-carboxamide; With sodium hydrogencarbonate; 1,2-dichloro-ethane; at 25 ℃; for 16h;

With methanol; for 3h; Reflux;

Reference yield:

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 1253190-73-6
N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)benzamido) piperidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrahydrofuran; methanol / 1 h / Reflux

1.2: 3 h / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 25 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; 1,2-dichloro-ethane / 16 h / 25 °C

3.2: 3 h / Reflux

With sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;