2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Base Information

Chemical Name:2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate
CAS No.:249572-34-7
Molecular Formula:C₄₃H₅₁N₆O₁₂P
Molecular Weight:874.885
Hs Code.:

Synonyms:2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

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Chemical Property of 2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

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Technology Process of 2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

There total 4 articles about 2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 2,2-dimethoxy-propyl ester

: 249572-34-7
2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: With pyridine; water; iodine; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/ja991574a

Reference yield:

: 99547-44-1
hydroxyacetone dimethylacetal

: 249572-34-7
2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole; 4A-molecular sieves / acetonitrile / 1.5 h / 0 - 20 °C

2: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; 1H-tetrazole; 4 A molecular sieve; water; iodine; In tetrahydrofuran; acetonitrile; 1: Condensation / 2: Oxidation;
DOI:10.1021/ja991574a

Reference yield:

: 10076-48-9
methyl 2,2-dimethoxypropionate

: 249572-34-7
2,2-dimethoxypropyl cyanoethyl 5'-O-(dimethoxytrityl)-N-isobutyryl-2'-deoxy-3'-guanylate

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / lithium aluminum hydride / diethyl ether / 1 h / 20 °C

2: tetrazole; 4A-molecular sieves / acetonitrile / 1.5 h / 0 - 20 °C

3: I₂; H₂O; pyridine / tetrahydrofuran / 0.33 h / 20 °C

With pyridine; 1H-tetrazole; lithium aluminium tetrahydride; 4 A molecular sieve; water; iodine; In tetrahydrofuran; diethyl ether; acetonitrile; 1: Reduction / 2: Condensation / 3: Oxidation;
DOI:10.1021/ja991574a