2-Acetoxy-2',4'-difluoroacetophenone

Base Information

• Chemical Name: 2-Acetoxy-2',4'-difluoroacetophenone
• CAS No.: 122263-03-0
• Molecular Formula: C10H8F2O3
• Molecular Weight: 214.169
• DSSTox Substance ID: DTXSID20570492
• Wikidata: Q72435559
• Mol file: 122263-03-0.mol

Synonyms:2-Acetoxy-2',4'-difluoroacetophenone;122263-03-0;2-(2,4-DIFLUOROPHENYL)-2-OXOETHYL ACETATE;Ethanone, 2-(acetyloxy)-1-(2,4-difluorophenyl)-;[2-(2,4-difluorophenyl)-2-oxoethyl] acetate;2-Acetyloxy-1(2,4-difluorophenyl)ethanone;MFCD09743655;2-ACETYLOXY-1-(2,4-DIFLUOROPHENYL)ETHANONE;SCHEMBL6947382;DTXSID20570492;OOCYQJABZIZEAJ-UHFFFAOYSA-N;AKOS015911868;s11835;DS-13675;SY114130;CS-0046842;2-Acetoxy-2' pound not4'-difluoroacetophenone;A891151;2-Acetoxy-2 inverted exclamation mark ,4 inverted exclamation mark -difluoroacetophenone

Chemical Property of 2-Acetoxy-2',4'-difluoroacetophenone

Chemical Property:

• PSA: 43.37000
• LogP: 1.71060
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 214.04415044
• Heavy Atom Count: 15
• Complexity: 255

Purity/Quality:

99% ^*data from raw suppliers

2-Acetoxy-2’,4’-difluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC(=O)C1=C(C=C(C=C1)F)F
• Uses: Intermediate in the production of antifungal agents.

Technology Process of 2-Acetoxy-2',4'-difluoroacetophenone

There total 4 articles about 2-Acetoxy-2',4'-difluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) + sodium acetate (127-09-3) → 2-Acetyloxy-1-(2,4-difluorophenyl)ethanone (122263-03-0)

Guidance literature:

In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1246/bcsj.69.2625

Reference yield:

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) → 2-Acetyloxy-1-(2,4-difluorophenyl)ethanone (122263-03-0)

Guidance literature:

With sodium acetate; In N,N-dimethyl-formamide;

Reference yield:

2-bromo-2',4'-difluoroacetophenone (102429-07-2) + sodium acetate (127-09-3) → 2-Acetyloxy-1-(2,4-difluorophenyl)ethanone (122263-03-0)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetasy.2009.09.024

upstream raw materials:

2-chloro-1-(2,4-dichlorophenyl)ethanone

sodium acetate

2-bromo-2',4'-difluoroacetophenone

Downstream raw materials:

2-(2,4-difluorophenyl)but-3-ene-1,2-diol

2-(tert-Butyl-dimethyl-silanyloxy)-1-(2,4-difluoro-phenyl)-ethanone

1-(2,4-Difluoro-phenyl)-2-(tetrahydro-pyran-2-yloxy)-ethanone

1-(2,4-difluorophenyl)-2-hydroxyethanone