10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III

Base Information

• Chemical Name: 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III
• CAS No.: 151672-48-9
• Molecular Formula: C₃₇H₅₂O₁₀S₂Si
• Molecular Weight: 749.031
• Mol file: 151672-48-9.mol

Synonyms:10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III

Chemical Property of 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III

There total 3 articles about 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-deacetylbaccatin III (32981-86-5,172018-16-5) → 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III (151672-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / imidazole / dimethylformamide / 25 °C

2: 1.) NaH / 1.) THF, 25 deg C

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)74046-9

Reference yield:

triethylsilyl chloride (994-30-9) → 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III (151672-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / imidazole / dimethylformamide / 25 °C

2: 1.) NaH / 1.) THF, 25 deg C

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)74046-9

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 7-triethylsilyl-10-deacetylbaccatin III (115437-18-8) + methyl iodide (74-88-4) → 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III (151672-48-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 25 deg C;

DOI:10.1016/S0040-4039(00)74046-9

upstream raw materials:

carbon disulfide

7-triethylsilyl-10-deacetylbaccatin III

methyl iodide

10-deacetylbaccatin III

Downstream raw materials:

C₅₄H₇₃NO₁₄S₂Si

C₃₉H₅₆O₁₀Si

C₃₈H₅₃NO₉Si

7-O-TES-10-formylethyl-10-deacetylbaccatin III