1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

Base Information

Chemical Name:1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene
CAS No.:792921-76-7
Molecular Formula:C₃₀H₅₈O₄Si₂
Molecular Weight:538.959
Hs Code.:

Synonyms:1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

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Chemical Property of 1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

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Technology Process of 1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

There total 13 articles about 1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 792921-75-6
(2R,4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 792921-76-7
1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

Guidance literature:: With 1H-imidazole; dmap;
DOI:10.1002/anie.200460593

Reference yield:

: 792911-23-0
(2R,4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4,6-tetramethylheptanamide

: 792921-76-7
1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / LDA; borane*ammonia complex / tetrahydrofuran; hexane / -78 - 20 °C

2: 95 percent / imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; dmap; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2007.05.033

Reference yield:

: 132969-64-3
tert-Butyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-dimethyl-silane

: 792921-76-7
1-(((2S,3R,4S,6R)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA; LiCl / tetrahydrofuran; hexane / -78 - 20 °C

1.2: 87 percent / tetrahydrofuran; hexane / 24 h / 20 °C

2.1: 96 percent / LDA; borane*ammonia complex / tetrahydrofuran; hexane / -78 - 20 °C

3.1: 95 percent / imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; dmap; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1.2: Meyers asymmetric alkylation;
DOI:10.1016/j.tet.2007.05.033