7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

Base Information

Chemical Name:7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine
CAS No.:1033610-05-7
Molecular Formula:C₂₅H₂₂BrNO₇
Molecular Weight:528.356
Hs Code.:

Synonyms:7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

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Chemical Property of 7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

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Technology Process of 7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

There total 6 articles about 7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1033610-42-2
7-bromo-3-iodo-6-methoxy-2-(4-methoxyphenyl)-furo[3,2-b]pyridine

: 201230-82-2
carbon monoxide

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1033610-05-7
7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methoxybenzene; at 90 ℃; for 120h; under 9308.91 Torr;

Reference yield:

: 4214-74-8
3,5-dichloropyridin-2-amine

: 1033610-05-7
7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen bromide; bromine; sodium nitrite / water / 1 h / 0 - 70 °C

1.2: pH 7

2.1: piperidine / bis-triphenylphosphine-palladium(II) chloride / 0.25 h

2.2: 1.5 h

3.1: sodium

3.2: 2 h / 80 °C

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

4.2: -78 - 20 °C

5.1: [bis(pyridine)iodine]⁺ tetrafluoroborate / tetrahydrofuran / 0.75 h / Heating / reflux

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methoxybenzene / 120 h / 90 °C / 9308.91 Torr

With piperidine; hydrogen bromide; bromine; tert.-butyl lithium; sodium; potassium carbonate; [bis(pyridine)iodine]⁺ tetrafluoroborate; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; methoxybenzene; pentane; 2.1: Sonogashira Coupling / 6.1: Carbonylative Suzuki Coupling;

Reference yield:

: 1033610-28-4
C₁₄H₉Cl₂NO

: 1033610-05-7
7-bromo-6-methoxy-2-(4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-furo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium

1.2: 2 h / 80 °C

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: -78 - 20 °C

3.1: [bis(pyridine)iodine]⁺ tetrafluoroborate / tetrahydrofuran / 0.75 h / Heating / reflux

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methoxybenzene / 120 h / 90 °C / 9308.91 Torr

With tert.-butyl lithium; sodium; potassium carbonate; [bis(pyridine)iodine]⁺ tetrafluoroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methoxybenzene; pentane; 4.1: Carbonylative Suzuki Coupling;