Technology Process of 7-bromo-3-iodo-6-methoxy-2-(4-methoxyphenyl)-furo[3,2-b]pyridine
There total 5 articles about 7-bromo-3-iodo-6-methoxy-2-(4-methoxyphenyl)-furo[3,2-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-bromo-3,5-dimethoxy-2-(4-methoxyphenylethynyl)pyridine;
With
[bis(pyridine)iodine]+ tetrafluoroborate;
In
tetrahydrofuran;
for 0.75h;
Heating / reflux;
With
water; sodium thiosulfate;
In
tetrahydrofuran; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen bromide; bromine; sodium nitrite / water / 1 h / 0 - 70 °C
1.2: pH 7
2.1: piperidine / bis-triphenylphosphine-palladium(II) chloride / 0.25 h
2.2: 1.5 h
3.1: sodium
3.2: 2 h / 80 °C
4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C
4.2: -78 - 20 °C
5.1: [bis(pyridine)iodine]+ tetrafluoroborate / tetrahydrofuran / 0.75 h / Heating / reflux
With
piperidine; hydrogen bromide; bromine; tert.-butyl lithium; sodium; [bis(pyridine)iodine]+ tetrafluoroborate; sodium nitrite;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; water; pentane;
2.1: Sonogashira Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: piperidine / bis-triphenylphosphine-palladium(II) chloride / 0.25 h
1.2: 1.5 h
2.1: sodium
2.2: 2 h / 80 °C
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C
3.2: -78 - 20 °C
4.1: [bis(pyridine)iodine]+ tetrafluoroborate / tetrahydrofuran / 0.75 h / Heating / reflux
With
piperidine; tert.-butyl lithium; sodium; [bis(pyridine)iodine]+ tetrafluoroborate;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; pentane;
1.1: Sonogashira Coupling;
