2-methyl-6-nitro-1H-Indole

Base Information

• Chemical Name: 2-methyl-6-nitro-1H-Indole
• CAS No.: 3484-23-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17200
• Hs Code.: 2933990090
• Mol file: 3484-23-9.mol

Synonyms:1H-Indole,2-methyl-6-nitro;2-methyl-6-nitro-indole;2-Methyl-6-nitro-indol;6-Nitro-2-methyl-indol;6-Nitro-2-methylindole;

Chemical Property of 2-methyl-6-nitro-1H-Indole

Chemical Property:

• Melting Point: 113.5-114.5 °C
• Boiling Point: 365.6±22.0 °C(Predicted)
• PKA: 15.34±0.30(Predicted)
• PSA: 61.61000
• Density: 1.355±0.06 g/cm3(Predicted)
• LogP: 2.90770
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-methyl-6-nitro-1H-Indole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-6-nitro-1H-Indole

There total 9 articles about 2-methyl-6-nitro-1H-Indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-hydroxy-2-methyl-6-nitroindole (1388183-58-1) → 2-methyl-6-nitro-1H-indole (3484-23-9)

Guidance literature:

With triethylamine; α-bromoacetophenone; In methanol; at 20 ℃; for 3h;

DOI:10.1055/s-0031-1291044

Reference yield: 58.0%

acetone (67-64-1) + 3-nitro-aniline (99-09-2) → 2-methyl-4-nitro-1H-indole (3484-10-4) + 2-methyl-6-nitro-1H-indole (3484-23-9)

Guidance literature:

With air; potassium tert-butylate; In dimethyl sulfoxide; for 2h;

DOI:10.1016/j.tet.2003.11.011

Reference yield: 33.0%

2-methyl-6-nitro-2,3-dihydro-1H-indole (51134-82-8) → 2-methyl-6-nitro-1H-indole (3484-23-9)

Guidance literature:

With chloranil; In xylene; at 140 ℃; for 2h;

DOI:10.1016/j.bmc.2008.04.059

upstream raw materials:

2-methyl-6-nitro-2,3-dihydro-1H-indole

6-fluoro-3-nitroaniline

acetone

3-nitro-aniline

Downstream raw materials:

6-amino-2-methylindole

4-(6-Butoxycarbonylamino-2-methyl-indol-1-ylmethyl)-3-methoxy-benzoic acid

4-(6-Butoxycarbonylamino-2-methyl-indol-1-ylmethyl)-3-methoxy-benzoic acid methyl ester

1-(2,6-dichlorobenzyl)-2-methyl-6-nitro-1H-indole

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