2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL

Base Information

• Chemical Name: 2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL
• CAS No.: 123752-64-7
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.261
• Hs Code.: 2922290090
• Mol file: 123752-64-7.mol

Synonyms:6<(dimethylamino)methyl>-2-methoxy-4-methylphenol

Chemical Property of 2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL

Chemical Property:

• Boiling Point: 106°/0.05mm

Purity/Quality:

98%min ^*data from raw suppliers

2-[(Dimethylamino)methyl]-6-methoxy-4-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL

There total 1 articles about 2-[(DIMETHYLAMINO)METHYL]-6-METHOXY-4-METHYLBENZENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Methoxy-4-methylphenol (93-51-6) + dimethyl amine (124-40-3) → 6<(dimethylamino)methyl>-2-methoxy-4-methylphenol (123752-64-7)

Guidance literature:

In water; for 1.5h;

DOI:10.1021/ja984182x

Reference yield: 52.0%

6<(dimethylamino)methyl>-2-methoxy-4-methylphenol (123752-64-7) → 3-methoxy-5-methyl-[1,2]benzoquinone (60824-63-7)

Guidance literature:

With potassiuim nitrosodisulfonate; In dichloromethane; for 0.25h; pH 6.1 (NA₂HPO₄/NaH₂PO₄);

DOI:10.1021/jo00288a048

Reference yield:

6<(dimethylamino)methyl>-2-methoxy-4-methylphenol (123752-64-7) → 2-(2,3-dimethoxy-5-methylphenyl)-4-oxopentanoic acid (223751-35-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) MeI / 1.) DMF, from 0 deg C to RT, 35 min, 2.) DMF, from 0 deg C to RT, 70 min

2: 1.) aq. LiOH, benzyltributylammonium chloride / 1.) CH₂Cl₂, 1 min, 2.) CH₂Cl₂, 5 min

3: 97 percent / aq. 25 percent NaOH / methanol / 24 h / Heating

4: 1.) LDA / 1.) THF, hexane, 0 deg C, 45 min, 2.) THF, hexane, from 0 deg C to RT, overnight

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, from -78 deg C to RT

With lithium hydroxide; sodium hydroxide; oxalyl dichloride; benzyltri(n-butyl)ammonium chloride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; methyl iodide; In methanol;

DOI:10.1021/ja984182x

upstream raw materials:

formaldehyd

2-Methoxy-4-methylphenol

dimethyl amine

Downstream raw materials:

3-methoxy-5-methyl-[1,2]benzoquinone

2-hydroxy-3-methoxy-5-methylphenylacetonitrile

2,3-dimethoxy-5-methylphenylacetonitrile

2-(2,3-dimethoxy-5-methylphenyl)acetic acid