3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Base Information

Chemical Name:3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
CAS No.:29580-36-7
Molecular Formula:C₂₃H₁₉ClN₂O
Molecular Weight:374.87
Hs Code.:

3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[<i>e</i>][1,4]diazepin-2-one

Synonyms:3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Technology Process of 3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

There total 4 articles about 3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 100-39-0
benzyl bromide

: 439-14-5
diazepam

: 29580-36-7
3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: With P-tris(dimethylamino)-C-dimethylphosphonium ylide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo9822030

Reference yield: 53.0%

: 78498-73-4
7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one lithium

: 100-44-7
benzyl chloride

: 29580-36-7
3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: In tetrahydrofuran; 1.) -20 deg C, 2.) room temp., 2 h;
DOI:10.1021/jo00333a002

Reference yield:

: 1088-11-5
desmethyldiazepam

: 29580-36-7
3-benzyl-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / (Me₂N)3PCMe₂ / tetrahydrofuran / 3 h / -78 - 20 °C

2: 55 percent / (Me₂N)3PCMe₂ / tetrahydrofuran / 2 h / 20 °C

With P-tris(dimethylamino)-C-dimethylphosphonium ylide; In tetrahydrofuran; 1: Methylation / 2: Methylation;
DOI:10.1021/jo9822030