ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate
CAS No.:1429510-35-9
Molecular Formula:C₁₆H₁₆BrN₃O₅
Molecular Weight:410.224
Hs Code.:

Synonyms:ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

There total 1 articles about ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 1364632-45-0
[(3S)-tetrahydrofuran-3-yl]hydrazine hydrochloride

: 99277-71-1
4-bromo-2-nitrobenzoic acid

: 1429510-35-9
ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

Guidance literature:: 4-bromo-2-nitrobenzoic acid; With thionyl chloride; In acetonitrile; for 3h; Reflux;

ethyl 3-(dimethylamino)acrylate; With triethylamine; In acetonitrile; at 10 - 35 ℃; for 3h;

[(3S)-tetrahydrofuran-3-yl]hydrazine hydrochloride; In water; acetonitrile; at 10 - 35 ℃; for 60h;

Reference yield:

: 1429510-35-9
ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate

: 1429511-40-9
Ethyl 5-(2-amino-4-bromophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazolo-4-carboxylate

Guidance literature:: ethyl 5-(4-bromo-2-nitrophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate; With sodium dithionite; In tetrahydrofuran; water; at 0 - 35 ℃; for 46h;

With hydrogenchloride; In tetrahydrofuran; water; at 10 - 35 ℃; for 3h;

With sodium hydroxide; In tetrahydrofuran; water;