threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione

Base Information

• Chemical Name: threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione
• CAS No.: 85260-55-5
• Molecular Formula: C₁₃H₁₅NO₂S₂
• Molecular Weight: 281.4
• Mol file: 85260-55-5.mol

Synonyms:threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione

Chemical Property of threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione

There total 2 articles about threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-propanoyl-1,3-thiazolidine-2-thione (85260-51-1) + benzaldehyde (100-52-7) → (2RS,3SR)-3-hydroxy-2-methyl-3-phenyl-1-(2-thioxo(1,3-thiazolidin-3-yl))propan-1-one (85260-55-5) + threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione (85260-55-5)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82423-6

Reference yield:

N-propanoyl-1,3-thiazolidine-2-thione (85260-51-1) + benzaldehyde (100-52-7) → (2RS,3SR)-3-hydroxy-2-methyl-3-phenyl-1-(2-thioxo(1,3-thiazolidin-3-yl))propan-1-one (85260-55-5) + threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione (85260-55-5)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82423-6

Reference yield: 95.0%

ethanol (64-17-5) + (2RS,3SR)-3-hydroxy-2-methyl-3-phenyl-1-(2-thioxo(1,3-thiazolidin-3-yl))propan-1-one (85260-55-5) → ethyl (2R*,3S*)-3-hydroxy-2-methyl-3-phenylpropanoate (17226-81-2,17226-82-3,24744-96-5,98857-57-9,98857-58-0)

Guidance literature:

With potassium carbonate; Ambient temperature;

DOI:10.1016/S0040-4020(01)82423-6

upstream raw materials:

N-propanoyl-1,3-thiazolidine-2-thione

benzaldehyde

Downstream raw materials:

ethyl (2R*,3S*)-3-hydroxy-2-methyl-3-phenylpropanoate

(2S,3R)-N-Benzyl-3-hydroxy-2-methyl-3-phenyl-propionamide

methyl 3-hydroxy-2-methyl-3-phenylpropanoate

(2S,3S)-3-(Isopropyl-dimethyl-silanyloxy)-2-methyl-3-phenyl-1-(2-thioxo-thiazolidin-3-yl)-propan-1-one