2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester
• CAS No.: 240401-27-8
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.304
• Hs Code.: 2934999090
• Mol file: 240401-27-8.mol

Synonyms:2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester;1,1-dimethylethyl 2-oxa-7-azaspiro[3,5]nonane-7-carboxylate;2-Oxa-7-azaspiro[3.5]nonane-7-carboxylicacid;2-oxa-7-azaspiro[3,5]nonane-7-carboxylic acid tert-butyl ester;tert-butyl 2-oxa-7-azaspiro[3.5]nonane-7-carboxylate;7-Boc-2-oxa-7-azaspiro[3.5]nonane, 95%;7-Boc-2-oxa-7-azaspiro[3....;2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-diMethylethyl

Chemical Property of 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 31-70°C
• Refractive Index: 1.503
• Boiling Point: 315.83 °C at 760 mmHg
• PKA: -0.80±0.20(Predicted)
• Flash Point: 144.809 °C
• PSA: 38.77000
• Density: 1.102 g/cm³
• LogP: 1.97180
• Storage Temp.: ?20°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-Oxa-7-azaspiro[3.5]nonane-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as an active pharmaceutical intermediate.

Technology Process of 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester

There total 11 articles about 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1,1-dimethylethyl 4-hydroxymethyl-4-methanesulfonyloxymethyl-1-piperidinecarboxylate (374794-85-1) → 2-oxa-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester (240401-27-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield: 66.0%

tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate (374794-84-0) → 2-oxa-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester (240401-27-8)

Guidance literature:

tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h;

With p-toluenesulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 1.5h;

With n-butyllithium; In tetrahydrofuran; at 0 - 60 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2011.04.054

Reference yield: 14.0%

C19H29NO6S → 2-oxa-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester (240401-27-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -10 - 60 ℃; for 4.5h;

upstream raw materials:

1,1-dimethylethyl 4-hydroxymethyl-4-methanesulfonyloxymethyl-1-piperidinecarboxylate

1-(tert-butyl) 4,4-diethyl piperidine-1,4,4-tricarboxylate

tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate

4-carbethoxypiperidine

Downstream raw materials:

cis-(RS)- and trans-(RS)-α-methyl-N-{4-[4-hydroxymethyl-4-(methoxymethyl)piperidin-1-yl]-1-phenylcyclohexyl}-3,5-bis(trifluoromethyl)benzeneacetamide

2-oxa-7-azaspiro[3,5]nonane acetic acid salt

C₁₅H₁₉NO₃

C₂HF₃O₂*C₇H₁₃NO