Technology Process of 4a-allyl-6-p-tolyl-2,3,4,4a-tetrahydro-1H-carbazole
There total 5 articles about 4a-allyl-6-p-tolyl-2,3,4,4a-tetrahydro-1H-carbazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); triethyl borane;
In
hexane; dichloromethane;
at 50 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/ol400110c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride) / dichloromethane / 24 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride / acetone / 1 h / Inert atmosphere
3.1: acetic acid / 140 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
4.2: 16 h / 0 - 20 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0); triethyl borane / dichloromethane; hexane / 16 h / 50 °C / Inert atmosphere
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); triethyl borane; difluoro-4-morpholinylsulfonium tetrafluoroborate; sodium hydride; acetic acid; triethylamine tris(hydrogen fluoride);
In
hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol400110c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / acetone / 1 h / Inert atmosphere
2.1: acetic acid / 140 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 16 h / 0 - 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0); triethyl borane / dichloromethane; hexane / 16 h / 50 °C / Inert atmosphere
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); triethyl borane; sodium hydride; acetic acid;
In
hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol400110c
