8,8-difluoro-1,4-dioxaspiro[4.5]decane

Base Information

• Chemical Name: 8,8-difluoro-1,4-dioxaspiro[4.5]decane
• CAS No.: 176251-49-3
• Molecular Formula: C₈H₁₂F₂O₂
• Molecular Weight: 178.179
• Hs Code.: 2932990090
• Mol file: 176251-49-3.mol

Synonyms:8,8-difluoro-1,4-dioxaspiro[4,5]decane

Chemical Property of 8,8-difluoro-1,4-dioxaspiro[4.5]decane

Chemical Property:

• Melting Point: 40-44 °C
• Boiling Point: 210.8±40.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

8,8-Difluoro-1,4-dioxaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8,8-difluoro-1,4-dioxaspiro[4.5]decane

There total 4 articles about 8,8-difluoro-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cyclohexanedione monoethylene ketal (4746-97-8) → 8,8-difluoro-1,4-dioxaspiro[4,5]decane (176251-49-3)

Guidance literature:

cyclohexanedione monoethylene ketal; With diethylamino-sulfur trifluoride; In dichloromethane; at 10 - 25 ℃; for 12h;

With boron trifluoride diethyl etherate; hydrogen fluoride; In triethylamine; at 5 - 30 ℃; for 12h; Solvent;

Reference yield: 60.0%

cyclohexanedione monoethylene ketal (4746-97-8) → 8,8-difluoro-1,4-dioxaspiro[4,5]decane (176251-49-3) + 8-fluoro-1,4-dioxaspiro[4.5]dec-7-ene (142273-44-7)

Guidance literature:

With pyrrolidinodifluorosulfiniumtetrafluoroborate; triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; for 3h; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.jfluchem.2013.05.019

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 8,8-difluoro-1,4-dioxaspiro[4,5]decane (176251-49-3) + 8-fluoro-1,4-dioxaspiro[4.5]decane

Guidance literature:

With ethanol; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

cyclohexanedione monoethylene ketal

8-fluoro-1,4-dioxaspiro[4.5]dec-7-ene

Downstream raw materials:

1-(4,4-difluorocyclohexyl)methanamine

1-amino-4,4-difluorocyclohexanecarboxylic acid

4a-allyl-6-p-tolyl-2,3,4,4a-tetrahydro-1H-carbazole

4,4-difluorocyclohexanone

Refernces

• 1、 -. "Method for synthesizing 8,8-difluoro-1,4- dioxaspiro[4.5]decane". Paragraph 0032-0039; 0046; 0054; 0059; 0064-0065; 0070; 0076. . Retrieved 2018/11/26.
• 2、 -. "Fused tricyclic hepatitis virus inhibitor and application thereof". Paragraph 0670; 0671; 0672; 0673. . Retrieved 2016/12/26.