N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Name:N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:928038-39-5
Molecular Formula:C₂₃H₁₇F₃N₄O₄
Molecular Weight:470.408
Hs Code.:

Synonyms:N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Property of N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Technology Process of N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 2 articles about N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 868736-13-4
4-(4-amino-2,5-difluorophenoxy)picolinamide

: 849217-48-7
((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

: 928038-39-5
N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid; With triethylamine; In tetrahydrofuran; for 0.25h; Inert atmosphere; Cooling with ice;

With thionyl chloride; In tetrahydrofuran; for 1.5h; Cooling with ice;

4-(4-amino-2,5-difluorophenoxy)picolinamide; With triethylamine; In tetrahydrofuran; at 0 ℃; for 24.75h; Cooling with ice;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 928038-39-5
N-(4-{[2-(Aminocarbonyl)pyridin-4-yl]oxy}-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.42 h / 20 °C

1.2: 2.5 h / 80 °C

2.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

2.3: 24.75 h / 0 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;