4-AMINO-5-BROMO-2-METHYLPYRIDINE

Base Information

• Chemical Name: 4-AMINO-5-BROMO-2-METHYLPYRIDINE
• CAS No.: 10460-50-1
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• Mol file: 10460-50-1.mol

Synonyms:3-Bromo-6-methyl-4-pyridinamine;4-Amino-5-bromo-2-methylpyridine

Chemical Property of 4-AMINO-5-BROMO-2-METHYLPYRIDINE

Chemical Property:

• Melting Point: 116.0-117.0 °C
• Boiling Point: 276.4°Cat760mmHg
• PKA: 7.63±0.42(Predicted)
• Flash Point: 120.9°C
• PSA: 38.91000
• Density: 1.593g/cm³
• LogP: 2.31590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-5-bromo-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-5-BROMO-2-METHYLPYRIDINE

There total 1 articles about 4-AMINO-5-BROMO-2-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-methyl-4-pyridinamine (18437-58-6) → 4-amino-5-bromo-2-methylpyridine (10460-50-1) + 4-amino-3-bromo-2-methylpyridine (97944-41-7) + 4-amino-3,5-dibromo-2-methylpyridine (126325-54-0)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; at 70 ℃; for 1h; Product distribution;

Reference yield: 76.0%

pivaloyl chloride (3282-30-2) + 4-amino-5-bromo-2-methylpyridine (10460-50-1) → C11H15BrN2O

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 15 ℃; for 10h;

Reference yield:

4-amino-5-bromo-2-methylpyridine (10460-50-1) → C18H21ClN2O2

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 10 h / 0 - 15 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

3-methyl-4-pyridinamine

Downstream raw materials:

N-[5-(3-chlorophenyl)-2-methylpyridin-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

C₁₇H₁₄ClN₅

Refernces