2-Chloro-3-(hydroxymethyl)phenol

Base Information

• Chemical Name: 2-Chloro-3-(hydroxymethyl)phenol
• CAS No.: 277331-17-6
• Molecular Formula: C7H7 Cl O2
• Molecular Weight: 158.584
• DSSTox Substance ID: DTXSID70573998
• Nikkaji Number: J803.872D
• Wikidata: Q82462860
• Mol file: 277331-17-6.mol

Synonyms:2-chloro-3-(hydroxymethyl)phenol;277331-17-6;BENZENEMETHANOL, 2-CHLORO-3-HYDROXY-;2-Chlor-3-oxy-benzylalkohol;SCHEMBL286832;2-chloro-3-hydroxymethylphenol;2-chloro-3-hydroxymethyl phenol;DTXSID70573998;VFCYCVIHXKLLNX-UHFFFAOYSA-N;CLA33117;MFCD16037273;Benzenemethanol, 2-chloro-3-hydroxy-;SY275170;CS-0378123;E86382

Chemical Property of 2-Chloro-3-(hydroxymethyl)phenol

Chemical Property:

• PSA: 40.46000
• LogP: 1.53790
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 158.0134572
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

BENZENEMETHANOL,2-CHLORO-3-HYDROXY 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)O)Cl)CO

Technology Process of 2-Chloro-3-(hydroxymethyl)phenol

There total 4 articles about 2-Chloro-3-(hydroxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.8%

2-Chloro-3-hydroxy benzoic acid (51786-10-8) → 2-chloro-3-(hydroxymethyl)phenol (277331-17-6)

Guidance literature:

With borane; In tetrahydrofuran; at 0 - 60 ℃;

Reference yield:

2-chloro-3-hydroxybenzaldehyde (56962-10-8) → 2-chloro-3-(hydroxymethyl)phenol (277331-17-6)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃; for 0.5h;

Reference yield:

2-chloro-3-hydroxybenzaldehyde (56962-10-8) → 2-Chloro-3-hydroxy benzoic acid (51786-10-8) + 2-chloro-3-(hydroxymethyl)phenol (277331-17-6)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

2-chloro-3-hydroxybenzaldehyde

meta-hydroxybenzaldehyde

2-Chloro-3-hydroxy benzoic acid

Downstream raw materials:

(2-chloro-3-hydroxymethylphenoxy)acetic acid methyl ester

4-bromo-2-chloro-3-(hydroxymethyl)phenol

3-(bromomethyl)-2-chlorophenol

2-chloro-3-methoxybenzyl alcohol