2-Chloro-3-hydroxybenzoic acid

Base Information

• Chemical Name: 2-Chloro-3-hydroxybenzoic acid
• CAS No.: 51786-10-8
• Molecular Formula: C7H5ClO3
• Molecular Weight: 172.568
• Hs Code.: 2918290000
• European Community (EC) Number: 848-247-0
• DSSTox Substance ID: DTXSID90576022
• Nikkaji Number: J2.158.999C
• Wikidata: Q82465530
• Mol file: 51786-10-8.mol

Synonyms:2-CHLORO-3-HYDROXYBENZOIC ACID;51786-10-8;2-Chloro-3-hydroxy-benzoic acid;MFCD09264192;Benzoic acid, 2-chloro-3-hydroxy-;2-chloro-3-hydroxybenzoicacid;hydroxychlorobenzoic acid;2chloro-3-hydroxybenzoic acid;SCHEMBL529909;2-chloro-3-hydroxy benzoic acid;DTXSID90576022;HMEJVKGZESKXFC-UHFFFAOYSA-N;CL9330;AKOS006331616;AB50521;CS-0145824;EN300-123515;Z1198219365

Chemical Property of 2-Chloro-3-hydroxybenzoic acid

Chemical Property:

• Melting Point: 156.5-157.5 °C
• Boiling Point: 333.1±27.0 °C(Predicted)
• PKA: 2.84±0.25(Predicted)
• PSA: 57.53000
• Density: 1.536±0.06 g/cm3(Predicted)
• LogP: 1.74380
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 171.9927217
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-hydroxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)O)Cl)C(=O)O

Technology Process of 2-Chloro-3-hydroxybenzoic acid

There total 16 articles about 2-Chloro-3-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Carboxyphenol (99-06-9) → 2-Chloro-3-hydroxy benzoic acid (51786-10-8)

Guidance literature:

With chlorine; In methanol; water; acetone; benzene;

Reference yield:

3-Carboxyphenol (99-06-9) → 2-Chloro-3-hydroxy benzoic acid (51786-10-8) + 2-chloro-5-hydroxybenzoic acid (56961-30-9)

Guidance literature:

With methanol; chlorine;

Reference yield:

2-chloro-3-trimethylsilanyloxy-benzoic acid → 2-Chloro-3-hydroxy benzoic acid (51786-10-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; cyclohexane; at 25 ℃; for 2h;

DOI:10.1016/j.tet.2004.10.103

upstream raw materials:

ethyl-3-hydroxybenzoate

2-chloro-3-hydroxybenzaldehyde

3-Carboxyphenol

3-hydroxyanthranilic acid

Downstream raw materials:

methyl 2-chloro-3-hydroxybenzoate

2-Chlor-3-(2-nitro-6-trifluormethyl-phenoxy)-benzoesaeure

2-Chlor-3-(6-chlor-2-nitro-phenoxy)-benzoesaeure

2-Chlor-3-(2-nitro-4-carboxy-phenoxy)-benzoesaeure