[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

Base Information

Chemical Name:[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate
CAS No.:1352245-01-2
Molecular Formula:C₂HF₃O₂*C₃₁H₃₄ClF₄N₅O
Molecular Weight:718.114
Hs Code.:

[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

Synonyms:[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

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Chemical Property of [4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

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Technology Process of [4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

There total 6 articles about [4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352246-49-1
(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

: 76-05-1
trifluoroacetic acid

: 163457-23-6
3,3-difluoropyrrolidine hydrochloride

: 1352245-01-2
[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

Guidance literature:: (3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone; 3,3-difluoropyrrolidine hydrochloride; With sodium acetate; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

With water; sodium hydroxide; In 1,2-dichloro-ethane;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 934989-28-3
benzyl (1R,2R)-2-(2,4-difluorophenyl)-4-oxo-cyclopentanecarboxylate

: 1352245-01-2
[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 12 h / 20 °C / 760.05 Torr / Inert atmosphere

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h / 20 °C

3: sodium acetate; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

With hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1352245-01-2
[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]-piperidyl]-[(1R,2R)-2-(2,4-difluorophenyl)-4-(3,3-difluoropyrrolidin-1-yl)cyclopentyl]methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: HATU / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium acetate; acetic acid / 1,4-dioxane / 16 h / 90 °C

3.1: dichloromethane / 16 h / 20 °C

4.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h / 20 °C

5.1: sodium acetate; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

With sodium acetate; sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; HATU; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;