(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Base Information

Chemical Name:(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone
CAS No.:1352246-49-1
Molecular Formula:C₂₇H₂₇ClF₂N₄O₂
Molecular Weight:512.987
Hs Code.:

Synonyms:(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Suppliers and Price of (3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

There total 5 articles about (3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352246-46-8
(1R,2R)-2-(2,4-difluorophenyl)-4-oxo-cyclopentanecarboxylic acid

: 1352246-27-5
4-[1-(4-chloro-3-methylphenyl)-3-methyl-1H-1,2,4-triazol-5-yl]piperidine trifluoroacetate

: 1352246-49-1
(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 934989-28-3
benzyl (1R,2R)-2-(2,4-difluorophenyl)-4-oxo-cyclopentanecarboxylate

: 1352246-49-1
(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 12 h / 20 °C / 760.05 Torr / Inert atmosphere

2: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h / 20 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1352246-49-1
(3R,4R)-3-[4-[2-(4-chloro-3-methyl-phenyl)-5-methyl-1,2,4-triazol-3-yl]piperidine-1-carbonyl]-4-(2,4-difluorophenyl)cyclopentanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: HATU / dichloromethane / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium acetate; acetic acid / 1,4-dioxane / 16 h / 90 °C

3.1: dichloromethane / 16 h / 20 °C

4.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 12 h / 20 °C

With sodium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; HATU; In 1,4-dioxane; dichloromethane;