2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

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Chemical Name:2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester
CAS No.:834906-36-4
Molecular Formula:C₃₈H₃₉NO₆
Molecular Weight:605.731
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

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Technology Process of 2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

There total 8 articles about 2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 834906-35-3
2,2-dimethyl-propionic acid 6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-quinolin-8-yl ester

: 834906-36-4
2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 9h;
DOI:10.1021/ja043904j

Reference yield:

: 139399-64-7
6-bromo-8-quinolinol

: 834906-36-4
2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / imidazole / dimethylformamide / 20 °C

2: 87 percent / imidazole; DMAP / CH₂Cl₂ / 2 h / 20 °C

3: 94 percent / aq. Cs₂CO₃ / dimethylformamide / 2 h / 20 °C

4: 86 percent / DMAP / pyridine / 6 h / 4 - 20 °C

5: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 9 h / 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja043904j

Reference yield:

: 103028-32-6
6-bromo-8-methoxy-quinoline

: 834906-36-4
2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / aq. HBr / 36 h / Heating

2: 55 percent / imidazole / dimethylformamide / 20 °C

3: 87 percent / imidazole; DMAP / CH₂Cl₂ / 2 h / 20 °C

4: 94 percent / aq. Cs₂CO₃ / dimethylformamide / 2 h / 20 °C

5: 86 percent / DMAP / pyridine / 6 h / 4 - 20 °C

6: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 9 h / 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; hydrogen bromide; caesium carbonate; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja043904j