2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

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Chemical Name:2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester
CAS No.:211758-76-8
Molecular Formula:C₃₅H₄₄N₂O₄S
Molecular Weight:588.811
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3282-30-2
pivaloyl chloride

: 211759-09-0
(E)-5-{4-Methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

: 211758-76-8
2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jo9801770

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 211758-76-8
2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 84 percent / PCl₃ / CHCl₃ / 40 h / Ambient temperature

2: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

3: 83 percent / methanol / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 0.5 h, 2.) THF, room temp., 40 min

5: 93 percent / Na/Hg, Na₂HPO₄ / methanol / 6 h / Ambient temperature

6: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 10 min

7: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 20 min, 2.) THF, room temp., 30 min

8: 80 percent / Bu₄NF / tetrahydrofuran / 20 h / Ambient temperature

9: 97 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

With dmap; sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; phosphorus trichloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jo9801770

Reference yield:

: 13508-96-8
2-methyl-4-nitro-pyridine

: 211758-76-8
2,2-Dimethyl-propionic acid (E)-5-{4-methoxy-2-[(E)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

2: 83 percent / methanol / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 0.5 h, 2.) THF, room temp., 40 min

4: 93 percent / Na/Hg, Na₂HPO₄ / methanol / 6 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 10 min

6: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 20 min, 2.) THF, room temp., 30 min

7: 80 percent / Bu₄NF / tetrahydrofuran / 20 h / Ambient temperature

8: 97 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

With dmap; sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo9801770