t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

Base Information

Chemical Name:t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate
CAS No.:1441792-98-8
Molecular Formula:C₂₁H₃₅FN₂O₃Si
Molecular Weight:410.604
Hs Code.:

Synonyms:t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

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Chemical Property of t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

There total 3 articles about t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1392196-69-8
(5-bromo-2-fluoro-phenoxy)-tert-butyl-dimethyl-silane

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1441792-98-8
t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In 1,4-dioxane; triethylamine; at 100 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1441792-98-8
t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14.5 h / 0 - 20 °C

2: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; triethylamine / 4.5 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In 1,4-dioxane; dichloromethane; triethylamine;

Reference yield:

: 112204-58-7
5-Bromo-2-fluorophenol

: 1441792-98-8
t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14.5 h / 0 - 20 °C

2: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; triethylamine / 4.5 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In 1,4-dioxane; dichloromethane; triethylamine;