(R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

Base Information

Chemical Name:(R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline
CAS No.:1441793-21-0
Molecular Formula:C₁₈H₂₀Cl₂FN₃
Molecular Weight:368.281
Hs Code.:

Synonyms:(R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

Chemical Property:

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Technology Process of (R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

There total 6 articles about (R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1441793-21-0
(R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C

1.2: 1 h / 20 °C

2.1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / triethylamine / 4 h / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-Mandelic acid; caesium carbonate; trifluoroacetic acid; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In ethanol; dichloromethane; triethylamine; isopropyl alcohol;

Reference yield:

: 1441793-16-3
(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

: 1441793-21-0
(R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1441793-10-7
t-butyl 4-(4-fluoro-3-(trifluoromethylsulfonyloxy)phenyl)piperazine-1-carboxylate

: 1441793-21-0
(R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / triethylamine / 4 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; trifluoroacetic acid; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In dichloromethane; triethylamine;