Technology Process of (R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline
There total 6 articles about (R)-N-(1-(2,4-dichlorophenyl)ethyl)-2-fluoro-5-(piperazin-1-yl)aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C
1.2: 1 h / 20 °C
2.1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / triethylamine / 4 h / 100 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); (S)-Mandelic acid; caesium carbonate; trifluoroacetic acid; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
In
ethanol; dichloromethane; triethylamine; isopropyl alcohol;
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / triethylamine / 4 h / 100 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; trifluoroacetic acid; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
In
dichloromethane; triethylamine;