(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

Base Information

Chemical Name:(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate
CAS No.:1441793-16-3
Molecular Formula:C₂₃H₂₈Cl₂FN₃O₂
Molecular Weight:468.399
Hs Code.:

Synonyms:(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

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Chemical Property of (R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of (R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

There total 4 articles about (R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1441793-10-7
t-butyl 4-(4-fluoro-3-(trifluoromethylsulfonyloxy)phenyl)piperazine-1-carboxylate

: 133773-29-2
(R)-2,4-dichloro-α-methylbenzylamine

: 1441793-16-3
(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In triethylamine; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1441793-16-3
(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C

1.2: 1 h / 20 °C

2.1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / triethylamine / 4 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-Mandelic acid; caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In ethanol; triethylamine; isopropyl alcohol;

Reference yield:

: 1441792-98-8
t-butyl 4-(3-(t-butyldimethylsilyloxy)-4-fluorophenyl)piperazine-1-carboxylate

: 1441793-16-3
(R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / triethylamine / 4 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In tetrahydrofuran; dichloromethane; triethylamine;