Technology Process of (R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate
There total 4 articles about (R)-t-butyl 4-(3-(1-(2,4-dichlorophenyl)ethylamino)-4-fluorophenyl)piperazine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
In
triethylamine;
at 100 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C
1.2: 1 h / 20 °C
2.1: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / triethylamine / 4 h / 100 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); (S)-Mandelic acid; caesium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
In
ethanol; triethylamine; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / triethylamine / 4 h / 100 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine;
In
tetrahydrofuran; dichloromethane; triethylamine;