3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Base Information

Chemical Name:3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
CAS No.:401566-08-3
Molecular Formula:C₂₄H₃₆N₄O₃S
Molecular Weight:460.641
Hs Code.:

Synonyms:3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

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Chemical Property of 3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

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Technology Process of 3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

There total 4 articles about 3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 401564-36-1
(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

: 2759-28-6
1-phenylmethylpiperazine

: 144-55-8
sodium hydrogencarbonate

: 401566-08-3
3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

Reference yield:

: 401564-30-5
3-[(2S,4R)-1-tert-butoxycarbonyl-4-hydroxy-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

: 401566-08-3
3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: DMSO; SO₃*pyridine

2: NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

With pyridine-SO₃ complex; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2007.01.110

Reference yield:

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 401566-08-3
3-[(2S,4S)-4-(4-benzyl-1-piperazinyl)-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl]-1,3-thiazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: HOBt; EDC / dimethylformamide

2: DMSO; SO₃*pyridine

3: NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

With pyridine-SO₃ complex; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.110